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Gm csf rheumatoid arthritis knee

GM-CSF was absolutely required for pain development.The role of GM-CSF was investigated using the collagenase-induced instability model of osteoarthritis. Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been shown to be important in the development of inflammatory models of rheumatoid arthritis and there is encouraging data that its blockade may have clinical relevance in patients with rheumatoid arthritis.Pain is one of the most important symptoms of OA as it causes a significant impairment in function.Granulocyte-macrophage colony-stimulating factor (GM-CSF) was originally defined as a hemopoietic growth factor [1].In the absence of GM-CSF, there was less synovitis and matrix metalloproteinase-mediated neoepitope expression at week 2 post disease induction, and less cartilage damage at week 6.Osteoarthritis (OA) is the most common rheumatic disorder.We studied both GM-CSF-/- mice and wild-type (C57BL/6) mice treated prophylactically or therapeutically with a monoclonal antibody to GM-CSF.

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